Name | 3-oxa-8-azabicyclo[3.2.1]octane |
Synonyms | LogP 8-oxa-3-aza-bicyclo 3-Oxa-8-azabicyclo[3.2.1]octane 3-oxa-8-azabicyclo[3.2.1]octane 3-Oxa-8-aza-bicyclo[3.2.1]octane 3-Oxa-8-aza-bicyclo[3.2.1]octane HCl 3-O×a-8-azabicyclo[3.2.1]octane hydrochloride 3-oxa-8-azabicyclo[3.2.1]octane hydrochloride (1R,5S)-3-oxa-8-azabicyclo[3.2.1]octane hydrochloride |
CAS | 904316-92-3 |
EINECS | 815-661-8 |
InChI | InChI=1/C6H11NO/c1-2-6-4-8-3-5(1)7-6/h5-7H,1-4H2 |
Molecular Formula | C6H11NO.ClH |
Molar Mass | 149.62 |
Density | 1.028g/cm3 |
Boling Point | 176.6°C at 760 mmHg |
Flash Point | 58.6°C |
Vapor Presure | 1.09mmHg at 25°C |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.469 |
uses | 3-oxa-8-azabicyclo [3.2.1] octane hydrochloride as an antagonist of the MDA receptor subunit NR2B, in the treatment of neurodegenerative disease effect is better. The research potential is large. |
synthesis method | with cheap and readily available adipic acid (1) as the initial raw material, followed by acid chlorination, benzylamine cyclization, hydrolysis, reduction, dehydration cyclization, hydrogen desorption of benzyl and salt formation, etc. 8-step reaction, synthesis of 3-oxa-8-azabicyclo [3.2.1] octane hydrochloride, the synthetic route is as follows. Fig.1 synthesis scheme of 3-oxa-8-azabicyclo [3.2.1] octane hydrochloride |